HYALURONAN RICH EMBRYO TRANSFER
Hyaluronic acid, also known as hyaluronan, is a glycosaminoglycan found extensively throughout the human body.
It is notably abundant in the female reproductive tract, specifically in the oviduct and uterus, making it a crucial molecule for applications in assisted reproduction.
It is a naturally occurring molecule within the body and serves as the primary glycosaminoglycan present in nearly all tissues, contributing to the formation of the extracellular matrix.
It is also present in fluids within follicles, oviducts, and uteri. With a multitude of functions, It plays roles in tissue hydrodynamics, cell movement, proliferation, and participates in various cell surface receptor interactions.
Notably, it differs from other glycosaminoglycans in the body by being synthesized in the plasma membrane rather than the Golgi apparatus and by existing as exceptionally large molecules.
Hyaluronan's Role in Facilitating Human Embryo Implantation in IVF
It has consistently demonstrated its ability to enhance implantation in humans. Utilizing a transfer medium containing a unique blend of hyaluronan and human recombinant albumin (EmbryoGlue) has shown improvements in pregnancy rates, implantation rates, and live birth rates.
Exploring Hyaluronan's Contribution to Assisted Reproductive Technology (ART)
In addition to promoting implantation, hyaluronan in conjunction with recombinant human albumin supports human embryo development during in vitro culture. Furthermore, research indicates that this combination significantly enhances embryo cryosurvival.